Scientists identify potential key to Lyme disease

Hello everyone,
I had to get this on the blog. This could be great news for Lyme disease patients. Let's hope this research is the real deal. I know many of us are hoping for a major breakthrough on this terrible disease. If you haven't watched the film "Under Our Skin", please do yourself a favor and buy the DVD. It is the best film ever made about Lyme disease, in my opinion. Go to http://www.underourskin.com to watch the extended trailer for the film. I hope everyone suffering with the aches and pains of Lyme disease will find comfort in this news article and the new film. Hang in there, miracles are starting to happen.

The best to everyone,
Richard



Feb. 9, 2009

Dallas, Texas
http://www.utsouthwestern.edu/utsw/cda/dept353744/files/517121.html

Researchers at University of Texas Southwestern Medical Center have
identified a protein that may help give Lyme disease its bite.

The findings suggest that the bacterial protein, which aids in
transporting the metal manganese, is essential for the bacterium that
causes Lyme disease to become virulent.

“We believe our findings provide a foundation for further defining metal homeostasis in this human pathogen and may lead to new strategies for thwarting Lyme disease,” said Dr. Michael Norgard, chairman of microbiology at UT Southwestern and senior author of a study now online and in an upcoming issue of the Proceedings of the National Academy of Sciences.

Lyme disease, discovered in 1977, is the most prevalent tick-borne
infection in the U.S. Borrelia burgdorfei, the bacterium that causes
Lyme disease, lives in infected mammals and in the midgut of ticks. When
an infected tick bites an animal or a human, the bacteria are
transmitted to the new host. Infection causes fever, malaise, fatigue,
headache, muscle and joint aches, and a characteristic “bull’s-eye” rash
that surrounds the site of infection.

To establish infection, however, the bacterium also must acquire a
number of essential nutrients, including metals like manganese from its
mammalian and tick hosts. Until now, no metal transporter responsible
for this acquisition had been identified in this bacterium.

In the current study, microbiologists examined whether bacteria
genetically engineered to lack this manganese transporter, called BmtA,
transmitted Lyme disease to ticks and mice. The bacterium lacking the
transporter, Dr. Norgard said, grows a bit more slowly in the test tube
but is not dramatically different from the normal version.

“When you try to grow it in a mouse, however, it can’t grow,” he said.
“The fact that the bacterium without this particular manganese
transporter can’t grow in a mouse raises important questions about what
aspects of physiology and metabolism contribute to the pathogenicity of
the organism.”

Lead author Dr. Zhiming Ouyang, postdoctoral researcher in microbiology
at UT Southwestern, said another newly discovered characteristic about
the bacterium that causes Lyme disease is that it doesn’t seem to
require iron to function, something most other pathogens need to survive.

“Out of the thousands of bacteria known, the Lyme disease agent and only
one or two other bacterial species do not require iron for growth,” Dr.
Ouyang said. “That raises the question as to what other metal co-factors
the Lyme disease bacterium depends on to carry out the work that iron
does for all these other biological systems. Our research suggests that
manganese is a really important one.”

The next step is to understand the exact mechanism of how manganese
functions in the organism.

“I really think that there’s also something to the notion that manganese
may regulate the expression of other virulence factors,” Dr. Norgard
said. “It could be that manganese has more of an indirect effect, but
more research is needed to determine what must happen for Borrelia
burgdorfei to become virulent.”

Researchers from Indiana University School of Medicine collaborated on
the study.

The research was funded by the National Institute of Allergy and
Infectious Diseases.

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Hi My Friends,
I am sure many of you have heard about a new movie about people dealing with Lyme Disease. The title of this movie is "Under our Skin." On November 14th, UNDER OUR SKIN received two prestigious awards at the annual Freddie Awards, sponsored by the International Health and Medical Media Awards and considered to be the “Oscars of health care films.” At the black-tie event in Philadelphia’s historic Crystal Tea Room, film Producer/Director Andy Abrahams Wilson accepted the award for Best Production in the category of Infectious Diseases. In his acceptance speech, he noted the importance of this validation by the medical establishment, and thanked the judges for helping raise the visibility of chronic Lyme disease. Former CNN health reporter and author Daryn Kagan, the event MC, also presented UNDER OUR SKIN with one of the top overall awards, the Robert E. Wise Award for Outstanding Cinematography, chosen from all the 32 category winners. In addition to these honors, another Open Eye Pictures production, THE CAREGIVERS, was recognized as a Finalist in the category of Caregiving.(Underourskin.com/blog/?p=80. You can watch a trailer and some excerpts of the movie on this Website and their Blog. I have ordered my copy of the movie and can't wait to watch the whole movie. This movie will do a great deal in helping people unfamiliar with Lyme disease, just how devastating it can be. The movie is extremely well done and full of heart tugging stories. Do yourself a real favor and watch this movie.!

Be well,
Richard

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Hello everyone.....sorry I have been gone!

Hi friends,

Please accept my apologies for not posting some new information for quite sometime. Having chronic Lyme disease is a reality I have to deal with. Sometimes, it flares up and it tends to take you down for a while. I have been experiencing a real flareup the past few months. I merely took a normal step one night and broke two bones in my right foot. I didn't drop anything on it or anything, it just broke two bones. I was having some problems of swelling in my feet and legs, but it has been attributed to erffects of Lyme disease. I got to have a cast for six weeks, but everything is better in that area right now. For those of you raeding this that have Lyme disease you will know what I mean when I say, I have had pain from the top of my head to the tips of my toes. It hurts to move. I am going to water therapy to help, but the process is slow. Nevertheless, I will try and introduce some new products, websites and and some current activity about Lyme disease treatment over the nest couple of weeks.

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I will talk with you again soon.
Be well,
Rich Bowman

p.s. If there is anyone out ther who has Lyme disease, who is having good luck with a product or treatment, I would love to hear from you. If you need someone to talk to about your disease, I would love to talk with you anytime. I would love to hear about a treatment for chronic Lyme disease and what type of symptoms that you have.

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Hello, my bloggingfriends,

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